Association between Vitamin D Receptor Gene Fok1 Polymorphism and Bone Mineral Density in a Population of Postmenopausal Women with Osteoporosis

AkhavanNiaki, Haleh and Shomali, Tayebeh and Asouri, Mohsen and Hashemi, Seyed MohammadBagher and Haghi, Hamed and Khorshidi, Mohammad and Ataee, Ramin and Ahmadi, Ali Asghar and Kavosian, Saeid and Amirbozorgi, Gali (2014) Association between Vitamin D Receptor Gene Fok1 Polymorphism and Bone Mineral Density in a Population of Postmenopausal Women with Osteoporosis. Journal of Mazandaran University of Medical Sciences, 24 (118). pp. 73-82.

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Official URL: http://jmums.mazums.ac.ir/article-1-4652-en.html

Abstract

Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study aimed at investigating the relationship between Vitamin D3 receptor polymorphism and estrogen levels in postmenopausal women with severe osteoporosis. Material and methods: The study population were 173 women including 91 postmenopausal women with osteoporosis and 82 women without osteoporosis (control group) aged 45-60 years of old. The study was carried out during 2011-2012. After extraction of genomic DNA from peripheral blood, FokI polymorphism (rs2228570) of the Vitamin D Receptor Gene (VDR) was investigated using polymerase chain reaction with restriction enzyme digestion (PCR-RFLP) method. Also, its relationship with bone mineral density (Bone Mineral Density) BMD, T-score, and Z-score was investigated. Results: According to the results, there was no association between rs2228570 and osteoporosis. We observed significant differences in bone density between the two groups (P<0.001). Conclusion: According to the findings, the association between genotype polymorphisms of vitamin D3 and osteoporosis is still unknown and other polymorphisms might affect bone density.

Item Type: Article
Uncontrolled Keywords: Polymorphism, vitamin D3 receptor, postmenopausal women, osteoporosis, BMD
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 15:18
Last Modified: 04 Jan 2018 15:18
URI: http://eprints.mazums.ac.ir/id/eprint/960

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