Investigating Factor V Leiden and Prothrombin G20210A Gene Mutation in Relation with Acute Myocardial Infarction

Hashemi, Seyyed Mohammad Javad and Janbabai, Ghasem and HashemiSoteh, Seyyed Mohammad Bagher and Shekarriz, Ramin and Mahdavi, Mohammad Reza and Ghaemian, Ali and Amini, Nosrat (2014) Investigating Factor V Leiden and Prothrombin G20210A Gene Mutation in Relation with Acute Myocardial Infarction. Journal of Mazandaran University of Medical Sciences, 24 (117). pp. 21-28.

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Official URL: http://jmums.mazums.ac.ir/article-1-4455-en.html

Abstract

Background and purpose: Beside the environmental determinants there are major genetic factors that could cause Myocardial Infarction (MI). The aim of this study was to clarify the relationship between factor V Leiden and prothrombin G20210A with acute MI in patients younger than 50 years of age. Materials and methods: In this case-control study we recruited 101 MI patients and 101 healthy individuals in Fatemeh Zahra Hospital, affiliated to Mazandaran University of Medical Sciences. Demographic information and risk factors including age, past history of MI, diabetes mellitus, hypertension, dyslipidemia, and smoking were recorded. Genes of factor V Leiden and prothrombin G20210A were analyzed using PCRRFLP method. Results: Among all subjects, 191 (94.55) had no factor V Leiden gene, 10 (4.95 ) were heterozygous, and one (0.49) was homozygous. In case group, and control group there were seven (6.9) and three (2.97) heterozygous for factor V Leiden, respectively (P= 0.27). There was no mutation of prothrombin G20210A gene in 197 (97.5) individuals and only five (2.5) were heterozygous. There was no statistically significant difference between the two groups (P= 0.17). Conclusion: The prevalence of factor V Leiden and prothrombin G20210A gene mutation, in patients was not significantly different from that of the normal individuals. However, further studies are recommended in this age group to investigate these factors.

Item Type: Article
Uncontrolled Keywords: Myocardial infarction, factor V Leiden, prothrombin G20210A
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 18:57
Last Modified: 04 Jan 2018 18:57
URI: http://eprints.mazums.ac.ir/id/eprint/929

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