Distribution Rates and Antibiotic Resistance Pattern of Enterococcus Spp. Isolated from Clinical Specimens of Hospitals in Hamedan

NajafiMosleh, Mohammad and Nasaj, Mona and Rahimi, Fateh and Arabestani, Mohammad Rez (2014) Distribution Rates and Antibiotic Resistance Pattern of Enterococcus Spp. Isolated from Clinical Specimens of Hospitals in Hamedan. Journal of Mazandaran University of Medical Sciences, 24 (117). pp. 92-102.

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Official URL: http://jmums.mazums.ac.ir/article-1-4445-en.html

Abstract

Background and purpose: Multi-resistant enterococci are important nosocomial pathogens that are shown to have high prevalence in recent years. Knowledge of antimicrobial resistance pattern is essential to formulate treatment guidelines for infections caused by enterococci. The aim of this study was to investigate the antimicrobial resistance among enterococci isolated from Hamedan hospitals. Material and methods: The study was carried out during 2012-2014 in 242 Enterococcus faecalis and Enterococcus faecium Strains isolated from clinical specimens of teaching inpatients and outpatients hospitals in Hamedan. Identified species by biochemical methods were confirmed by PCR. Antibiotic resistance was performed by disk diffusion. MIC (Minimum Inhibitory Concentration) of vancomycin and Teicoplanin were determined by Microdilution Broth method. Results: A total of 280 enterococcal isolates were studied of which, 175 (62.5) were identified as Enterococcus faecalis, 67(24) as Enterococcus faecium, and 38(13.5) as Enterococcus spp. No resistance to Linezolid and Nitrofurantoin was detected among E.faecalis isolates. All isolates of E. faecium were susceptible to Linezolid. Resistance rates to ampicillin, Vancomycin, Teicoplanin, ciprofloxacin, erythromycin, Norfloxacin, gentamicin and Nitrofurantoin were found higher in E.faecium isolates than those of the E.faecalis group. Conclusion: Due to the high prevalence of Vancomycin-resistant enterococci and also increasing resistance of enterococcus to most common antibiotics, there is a need for preventive and control measurements. Therefore, antibiotic susceptibility testing is recommended for all patients before prescription of appropriate antibiotics.

Item Type: Article
Uncontrolled Keywords: Enterococcus faecalis, Enterococcus faecium, antibiotic resistance, minimal inhibitor concentration
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 18:56
Last Modified: 04 Jan 2018 18:56
URI: http://eprints.mazums.ac.ir/id/eprint/910

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