A Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis

Fakhar, Mahdi and Azadbakht, Mohammad and Davoodi, Ali and Eslami, Shahram and ZiaeiHezarjaribi, Hajar and Keighobadi, Masou (2020) A Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis. Journal of Mazandaran University of Medical Sciences, 30 (185). pp. 173-183.

Full text not available from this repository.
Official URL: http://jmums.mazums.ac.ir/article-1-14137-en.html

Abstract

There is a high prevalence of infections caused by Leishmania parasites and increasing rate of drug resistance. Lack of successful treatment with existing drugs calls for new therapeutic approaches. The main strategy in treatment of leishmaniasis is creating apoptosis and eliminating different forms of the parasite. So far, numerous drugs with specific mechanisms including 14-α-demethylase enzyme inhibition, inhibition of tubulin polymerization and cell division, radical formation, inhibiting the glycolytic and hydrolysis of fatty acids, and reducing the parasite's access to energy reserves such as ATP have been introduced. Moreover, different mineral compounds especially iron are needed for metabolism and survival of the parasite. This review article introduces iron-chelating compounds as a new therapeutic approach in treatment of leishmaniasis.

Item Type: Article
Uncontrolled Keywords: leishmania, iron chelating agent
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 01 Jul 2020 08:40
Last Modified: 01 Jul 2020 08:40
URI: http://eprints.mazums.ac.ir/id/eprint/5739

Actions (login required)

View Item View Item