Influence of Diosmin on Post hemorrhoidectomy Pain: A Si gle-blind n Randomized Controlled Trial

Alvandipoor, Mina and Mahdavi, Ali and Nouri, Banafshe (2019) Influence of Diosmin on Post hemorrhoidectomy Pain: A Si gle-blind n Randomized Controlled Trial. Journal of Mazandaran University of Medical Sciences, 29 (177). pp. 91-98.

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Background and purpose: Fear of pain is one of the main reasons for refusing surgical hemorrhoidectomy among patients with hemorrhoids. This study investigated the effect of Diosmin on post-hemorrhoidectomy pain. Materials and methods: A single-blind randomized clinical trial was performed in 92 patients undergoing hemorrhoidectomy. They were randomly divided into two groups; the intervention group (n=46) received Diosmin 500 mg daily, and the placebo group (n=46) received a tablet daily. Both groups were examined after a week. Duration of hospitalization, return to work, and time of complete recovery and pain were also examined. Data analysis was done in SPSS V18. Results: The mean age of patients was 37.55±12.21 years. In both groups, distribution of population was completely homogeneous in terms of age (0.833), gender (1.00), degree of hemorrhoids (0.538), mucous secretion (0.514), duration of hospitalization (0.821), return to work (0.754), complete recovery (0.631), and postoperative bleeding (0.557) showing no significant relationship between the two groups (0.557). The mean pain intensity was 3.41±1.292 in intervention group and 4.65±1.370 in the placebo group which showed a significant difference between the two groups after the intervention (P=0.000). Conclusion: Diosmin can be used as a safe drug with minimal side effects to control post-hemorrhoidectomy pain.   (Clinical Trials Registry Number: IRCT20180717040509N1) <p).</p).

Item Type: Article
Uncontrolled Keywords: Diosmin, pain, hemorrhoidectomy
Depositing User: Unnamed user with email
Date Deposited: 22 Dec 2019 05:35
Last Modified: 22 Dec 2019 05:35

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