The effect of Eudragit RLPO and HPMC (K100M) on dissolution rate of metformin from liquisolid compacts

Anahita Asadi, (2019) The effect of Eudragit RLPO and HPMC (K100M) on dissolution rate of metformin from liquisolid compacts. Doctoral thesis, School of Pharmacy.

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Background and purpose: Liquisolid system has been used to increase the dissolution rate of hydrophobic drugs but recently it was also used to control drug release via appropriate solvent The aim of this study was to investigate the effect of different liquid vehicles and Eudragit RLPO on release characteristics of metformin. Materials and Methods: several Liquisolid compacts with glycerin and tween20 with different drug: solvent ratio were prepared the ratio of carrier material (Eudragit RLPO alone or with different ratio of microcrystalline cellulose) to coating material (silica) was 2 in all formulations. To evaluate any interaction between metformin and the other components, the differential scanning calorimeter (DSC) and Fourier transform infrared spectroscopy (FTIR) was used Results: Liquisolid formulations, displayed significantly higher drug dissolution rates compared to the compacts prepared by the direct compression technique. Additionally, increasing of the nonvolatile solvent ratio: drug in liquid medication caused a remarkable enhancement in dissolution rate. The dissolution profile and hardness of liquisolid tablets were not significantly affected by storing the tablets at 25 oC in a relative humidity of 75% for a period of 6 months. The DSC and FTIR data were not revealed any changes in crystallinity of the drug and interaction between drug and excipients during the process. Conclusion: Findings of this study suggested that the Type of nonvolatile solvent has an important role on liquisolid release profile .The liquisolid compacts with the suitable carrier can be promising technique to sustain release drugs Key words: Metformin, Sustain release, Eudragit RLPO, Liquisolid system

Item Type: Thesis (Doctoral)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Unnamed user with email
Date Deposited: 17 Dec 2019 08:19
Last Modified: 17 Dec 2019 08:19

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