Study on seroprevalence of cytomegalovirus in pregnant women reffered to Mehr Institute and the association of cytomegalovirus seropositivity to spontaneous abortion

Janan, Armaghan and Honarmand, Hamidreza and Amirmozafari, Noor and Asgharnia, Masoumeh and Janan, Arghav (2013) Study on seroprevalence of cytomegalovirus in pregnant women reffered to Mehr Institute and the association of cytomegalovirus seropositivity to spontaneous abortion. Journal of Mazandaran University of Medical Sciences, 23 (105). pp. 36-42.

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Official URL: http://jmums.mazums.ac.ir/article-1-2761-en.html

Abstract

Background and purpose: Primary cytomegalovirus (CMV) infection occurs in 0.15-2.0 of all pregnancies and might causes abortion. Actually CMV infections are most common in females and rate of infection increases with age. In pregnant women it usually occurs in ages below 30 years old. Aim of the present study was investigating on the seropositivity rate of CMV in pregnant women to determine the rates of infections (primary, reinfection, and reactivated) in them and to find the rates of abortion due to these infections Material & methods: The present study 360 pregnant women were screened for CMV-IgG ELISA to reveal seroprevalence rate in them. Type of CMV infection (primary, reinfection, reactivated and incidious infection) were investigated in them by using CMV-IgM, CMV-IgG, and CMV-IgG Avidity tests. All cases were followed to the end of pregnancy. Results: CMV-IgG seroprevalence in studied women was 77.3 and high rate seropositivity was 50.4. Frequency of primary, reinfection and reactivated infections was 0.8, 0.6, and 21.1 respectively. Insidious infection rate was 54.7. About 22.8 of studied women had not exposured with CMV before screening. Abortion occurred in about 66.7 of primary infections and 100.0 of reinfections and these two factors presented significant relationship with spontaneous abortion. Conclusion: Results of the present study showed seropositivity for CMV-IgG is not a valuable measure for CMV active infection even with high titers, so screening with CMV-IgG in pregnancy in not valuable without CMV-IgG avidity test but regarding to significant relationship of primary and reinfection with abortion, It seems that follow up of pregnant women for these infections with IgM-CMV ELISA might be more worthy.

Item Type: Article
Uncontrolled Keywords: Cytomegalovirus, Seroprevalence, Spontaneous abortion
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 19:14
Last Modified: 04 Jan 2018 19:14
URI: http://eprints.mazums.ac.ir/id/eprint/515

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