Efficacy of Prophylactic Low Dose Ketamine in Preventing Shivering after General Anesthesia

Hasannasab, Bahman and Banihashem, Nadia and Khoshbakht, Afshin and Shirkhani, Zib (2013) Efficacy of Prophylactic Low Dose Ketamine in Preventing Shivering after General Anesthesia. Journal of Mazandaran University of Medical Sciences, 23 (103). pp. 89-93.

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Official URL: http://jmums.mazums.ac.ir/article-1-2513-en.html


Background and purpose: Post anesthetic shivering is a common and unpleasant postoperative complication. The aim of this study was to evaluate the efficacy of low-dose prophylactic ketamine in preventing postoperative shivering after general anesthesia. Materials and methods: A double-blind randomized controlled trial was carried out in 60 patients of ASA class I-II undergoing general anesthesia. General anesthesia was performed with fentanyl, midazolam, sodium thiopental and atracurium. The patients were randomly allocated to receive either saline 0.9 or ketamine 0.25 mg kg�1 intravenously at the beginning of wound closure. Occurrence and severity of shivering was evaluated for 30 min in the recovery room. Side effects were also assessed in the recovery room. Results: In postoperative period incidences of shivering were 36.07 and 6.7 in control group and ketamine group, respectively. The difference between ketamine group and control group was statistically significant. (P=0.005) The number of patients with shivering score of 2 was significantly higher in control group compared with that of the ketamine group. (p=0.02) The incidence of side effects was similar in the two groups. Conclusion: Prophylactic low dose ketamine (20mg) was effective in preventing postoperative shivering without significant side effect. (Clinical Trials Registry Number: IRCT201012224923N1)

Item Type: Article
Uncontrolled Keywords: Shivering, ketamine, general anesthesia
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 19:15
Last Modified: 04 Jan 2018 19:15
URI: http://eprints.mazums.ac.ir/id/eprint/490

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