Caspase 9 Promoter Polymorphisms in Gastric Cancer, Mazandaran Province

shokrzadeh, Mohammad and Abediankenari, Saeid and haghiaminjan, Hamed and Ghasemi, Maryam and Hoseini, Vahid and jeivad, Fereshteh and Alizadeh, Ahad and Farzad, Faramarz (2013) Caspase 9 Promoter Polymorphisms in Gastric Cancer, Mazandaran Province. Journal of Mazandaran University of Medical Sciences, 23 (98). pp. 2-7.

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Official URL: http://jmums.mazums.ac.ir/article-1-1952-en.html

Abstract

Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter could influence the gene activity and cause sensitivity to cancer. Materials and methods: In this case-control study, 100 patients with gastric cancer and 100 normal subjects were considered for caspase 9 promoter gene polymorphism. DNA extraction was performed from white blood cells according to manufacturer protocol. PCR-RFLP was carried out to detect -712 C>T gene polymorphism. Data was analyzed using SPSS V.18 and PT caspase 9 polymorphism could be a marker in personal sensitivity to gastric cancer and useful in cancer treatment and prevention process.

Item Type: Article
Uncontrolled Keywords: Caspase 9 promoter, gastric cancer, genetic polymorphism, PCR, Restriction fragment length polymorphism, RFLP-PCR
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 18:15
Last Modified: 04 Jan 2018 18:15
URI: http://eprints.mazums.ac.ir/id/eprint/409

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