Preparation, Characterization and Analgesic Evaluation of a Novel Physical Hydrogel Composed of Opened-ring poly (Vinyl Pyrrolidone) and Chitosan Containing Ostrich Oil in Mice

Ahangar, Nematollah and GhadamiRazdari, Masoud and Ebrahimnejad, Pedram (2018) Preparation, Characterization and Analgesic Evaluation of a Novel Physical Hydrogel Composed of Opened-ring poly (Vinyl Pyrrolidone) and Chitosan Containing Ostrich Oil in Mice. Journal of Mazandaran University of Medical Sciences, 28 (165). pp. 1-12.

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Official URL: http://jmums.mazums.ac.ir/article-1-11702-en.html

Abstract

Background and purpose: Hydrogels are used as carriers to control drug release. Ostrich oil has fatty acids which plays an important role in growth, division, and health of cells and cause wound healing and have anti-inflammatory effects. Materials and methods: In this experimental study, pH sensitive hydrogel was produced by chitosan deviation and open ring Poly-vinyl pyrrolidon (OR-PVP). The physicochemical characteristics of ostrich oil hydrogel was studied and its analgesic effect on mice was investigated by hot plate and formalin test. Results: Compared with other formulations, formulations containing chitosan with high molecular weight showed better results. The ratio of OR-PVP to high molecular chitosan was 0.4 for the best formulation. All formulations with 30 ostrich oil were found to have good analgesic effects. Conclusion: This study showed that ostrich oil hydrogel could reduce inflammation and central pain.  

Item Type: Article
Uncontrolled Keywords: hydrogel, ostrich oil, formalin test
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 31 Dec 2018 08:53
Last Modified: 31 Dec 2018 08:53
URI: http://eprints.mazums.ac.ir/id/eprint/3981

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