Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan

FaisalAli, Syed and Joshi, Monika and Akhtar, Nida and Sharma, Vijay and Pathak, Kaml (2016) Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan. Pharmaceutical and Biomedical Research, 2 (1). pp. 23-35.

Full text not available from this repository.
Official URL: http://pbr.mazums.ac.ir/article-1-91-en.html

Abstract

The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68, Gelucire 50/13 and Plasdone S630. A total of nine batches (SD1-SD9) were characterized for micromeritic properties, in vitro dissolution behavior and surface characterization. SD4 with 52.43 cumulative drug release (CDR) in phosphate buffer, pH 7.4, in 120 min, t50 44.2 min and DE30min 96.76 was selected for the development of semi-solid capsules. Differential scanning calorimetry of SD4 revealed molecular dispersion of TLMS in Pluronic-F68. SD4 was formulated into SSCs using Gelucire 44/14 and PEG 400 as semi-solid components and PEG 6000 as a suspending agent to achieve reduction in lag time for effective drug dissolution. SSC6 showed maximum in vitro drug dissolution 97.49 in phosphate buffer, pH 7.4 with in 20 min that was almost a three folds reduction in the time required to achieve similar dissolution by SD. Thus, SSCs present an excellent approach to enhance in vitro dissolution as well as to reduce the lag time of dissolution for poorly water soluble drugs especially to those therapeutic classes that are intended for faster onset of action. Developed approach based on HPMC capsules provided a better alternative to target delivery of telmisartan to the vegetarian population.

Item Type: Article
Uncontrolled Keywords: in vitro dissolution, lag time, HPMC capsules, solid dispersion, solubility
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 09:28
Last Modified: 04 Jan 2018 09:28
URI: http://eprints.mazums.ac.ir/id/eprint/350

Actions (login required)

View Item View Item