Evaluation of serum level of IL-12 in patients withoccult HBV infection

KazemiArababadi, M and Pourfathollah, A.A and Hassanshahi, GH.H and Pooladvand, V and Yaghini, N and Shamsyzadeh, A (2009) Evaluation of serum level of IL-12 in patients withoccult HBV infection. Journal of Mazandaran University of Medical Sciences, 19 (73). pp. 80-83.

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Official URL: http://jmums.mazums.ac.ir/article-1-592-en.html

Abstract

Background and purpose:Occult hepatitis B infection (OBI) is a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients. Materials and methods:In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls. Results:Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls. Conclusion:In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV.

Item Type: Article
Uncontrolled Keywords: Occult hepatitis B infection, IL-12, HBsAg, HBV-DNA
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 17:36
Last Modified: 04 Jan 2018 17:36
URI: http://eprints.mazums.ac.ir/id/eprint/3432

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