The study regarding effect of paraoxon on oxidative stress

Abbasnezhad, M and Jafari, M and Asgari, A.R and Hajihoseini, R and Hajigholamali, M and Salehi, M and Salimian, M (2009) The study regarding effect of paraoxon on oxidative stress. Journal of Mazandaran University of Medical Sciences, 19 (73). pp. 16-26.

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Official URL: http://jmums.mazums.ac.ir/article-1-584-en.html

Abstract

Background and purpose:Paraoxon is the active form of parathion, which is an organophosphate pesticide (OP). The toxic effects of some OPs are not limited to inhibition of cholinesterase, they are capable to produce free radicals and induce disturbance in body antioxidant systems. The purpose of this study was to evaluate the effect of paraoxon on oxidative stress indexin the kidney of rat. Materials and methods:Wistar male rats were randomly divided in four groups including: control (corn oil as paraoxon solvent) and three paraoxon groups receiving different doses (0.3, 0.7 and 1mg/kg) by intraperitoneal injection. 24 hours after injection, animal was given anesthesia and kidney tissue removed. After kidney tissue hemogenation, superoxidedismutase (SOD) and catalase (CAT), lactate dehydrogenase (LDH) and glutathione S- transferase (GST) activities, glutathione (GSH) and malondialdehyde (MDA) levels were determined by biochemical methods. Results:At doses higher than 0.3 mg/kg paraoxon, kidney SOD and CAT activities were significantly increased, comparing with the control, while GSH level was significantly decreased. There were no significant changes observed in GST, LDH activities and MDA levels. Conclusion:The results suggest that paraoxon induces the production of free radicals and oxidative stress. The enhanced activity of antioxidant enzymes in kidney of rats probably wasa function of the increased detoxification capacity. Depletion of tissue GSH is a prime factor, which can impair the cell�s defense against the toxic actions of free radicals.

Item Type: Article
Uncontrolled Keywords: Paraoxon, oxidative stress index, rat, kidney tissue
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 17:35
Last Modified: 04 Jan 2018 17:35
URI: http://eprints.mazums.ac.ir/id/eprint/3424

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