Evaluation of prevalence of d 32 mutation in CCR5 gene in breast cancer patients in Rafsanjan city

KazemiArababadi, M and Mirzaei, M.R and RezazadehZarandi, E and Hassanshahi, GH.H and VataniBaf, M.R (2009) Evaluation of prevalence of d 32 mutation in CCR5 gene in breast cancer patients in Rafsanjan city. Journal of Mazandaran University of Medical Sciences, 19 (70). pp. 49-53.

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Official URL: http://jmums.mazums.ac.ir/article-1-549-en.html

Abstract

Background and purpose: Chemokines and their receptors are expressed in different types of malignancies. CC chemokines MIP-1a (CCL3), MIP-1b (CCL4) and RANTES (CCL5) is believed to be anti-tumor and also aid to the metastasis in tumor microenvironment. CCR2 and CCR5 are special G-protein receptors for these chemokines. Due to the important role of CCR5 chemokine receptor in tumor biology, this project is designed to examine d 32 mutation in CCR5 gene regards breast cancer. Materials and methods: This experimental study was performed during 2007-8 on 100 healthy adults and 36 breast cancer patients by Gap-PCR. The demographic information also was collected by questionner and t-test Chi-square was used for statistical analysis of data. Results: Our results showed that none of breast cancer patients had CCR5-d 32 mutation while 3 (3) cases of controls had heterozygotic form of this mutation. Conclusion: Our results showed that there is not any CCR5-d 32 mutation in patients. Therefore, it appears that this mutation don�t play any role in breast cancer.

Item Type: Article
Uncontrolled Keywords: Chemokine, CCR5, d 32 and breast cancer
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 17:40
Last Modified: 04 Jan 2018 17:40
URI: http://eprints.mazums.ac.ir/id/eprint/3378

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