Incidence of chemotherapy-induced amenorrhea in non-menopausal women with breast cancer

Keihanian, SH and Fotokian, Z and Ghaffari, F and Vahdani, M and Shirinkam, F and Saravi, M.M (2009) Incidence of chemotherapy-induced amenorrhea in non-menopausal women with breast cancer. Journal of Mazandaran University of Medical Sciences, 19 (70). pp. 9-17.

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Official URL: http://jmums.mazums.ac.ir/article-1-544-en.html

Abstract

Background and purpose: Although adjunct chemotherapy may increase life in non-menopausal breast cancer patients� however� it may cause short-term complications such as nausea� vomiting� alopecia� as well as long-term complications in ovarian failure and premature menopausal. The objective of this study was to investigate chemotherapy-induced secondary amenorrhea in non-menopausal women with breast cancer. Materials and methods: A descriptive design (case series) was preformed on fifty breast cancer patients� non-menopausal (normal mense) and chemotherapy in Ramsar Emam Sajad Hospital Oncology unit from 2007 to 2008. Sampling was consecutive. Data gathering method was questionnaire & blood sampling (FSH & Progesterone) for prior and 12 months after the end of chemotherapy. Data was analyzed by paired-t� independent-t and one-way ANOVA tests. Results: Results showed that 62 of patients were amenorrhea 12 months after the end of chemotherapy. Results showed that there was no meaningful relationship between age� hormone therapy� disease stage� node-positive and ER & PR status to amenorrhea however� there was a meaningful relationship between duration of treatment� type and dose of chemotherapy to amenorrhea. Conclusion: In pre-menopausal patients with breast cancer� receiving cytotoxic chemotherapy against tumor cells� amenorrhea may occur do to ovarian failure.

Item Type: Article
Uncontrolled Keywords: Breast cancer, amenorrhea, chemotherapy, on, menopausal women
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 17:40
Last Modified: 04 Jan 2018 17:40
URI: http://eprints.mazums.ac.ir/id/eprint/3373

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