The survey of anti-inflammatory effect of bisphosphonates

Shiari, R and Nasehi, M.M and Farivar, SH and Hatamian, B (2009) The survey of anti-inflammatory effect of bisphosphonates. Journal of Mazandaran University of Medical Sciences, 19 (69). pp. 79-87.

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Bisphosphonates are currently used in metabolic disorder of bone however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in-vivo. Bisphosphonates were divided in two classes regarding the structure and mechanism, including amino and non-amino bisphosphonates. The effect of bisphosphonates on cytokine related to in-vitro was complex and related to type and dose of bisphosphonates, examination of cell type and cell culture evaluation system. However, amino bisphosphonates activated inflammatory cytokine regarding to in-vivo and chronic usage of this agent, can stop the production of these cytokines. Present study surveyed the anti -inflammatory and immune modulatory effect of bisphosphonates and clinical trial, along with recent knowledge about potential mechanism of this component.

Item Type: Article
Uncontrolled Keywords: Biphosphonate, anti-inflammatory, immuno modulatory
Depositing User: Unnamed user with email
Date Deposited: 04 Jan 2018 17:42
Last Modified: 04 Jan 2018 17:42

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