Magnesium Sulfate Pretreatment to Alleviate Pain on Propofol Injection: A Comparison with Ketamine or Lidocaine

Safavi, M.R and Honarmand, A (2007) Magnesium Sulfate Pretreatment to Alleviate Pain on Propofol Injection: A Comparison with Ketamine or Lidocaine. Journal of Mazandaran University of Medical Sciences, 17 (60). pp. 30-38.

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Official URL: http://jmums.mazums.ac.ir/article-1-248-en.html

Abstract

Background and purpose: Propofol causes pain and hypotension when it was injected. Magnesium (Mg) and ketamine are antagonists of the N-methyl-d-aspartate (NMDA) receptor ion channel and cause analgesia. In view of the analgesic activity of Mg and ketamine, we tested the effect of intravenous administration of magnesium sulfate in reducing pain induced by propofol. Materials and Methods:Two hundred ASA I-II adults patients undergoing elective ophthalmic surgery were randomly assigned into four groups of 50 subjects in each groups. Group M received magnesium sulfate 2.48 mmol, Group K received ketamine 10 mg, Group L received lidocaine 1 (30 mg) and Group C received normal saline, all in a volume of 5 mL followed by 5 mL of 1 propofol 30 s later. Pain was assessed on a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain at the time of pretreatment and propofol injection. Results:Eighty-eight percent of patients in the control group had pain during iv propofol as compared to 34, 28, and 18 in the magnesium, ketamine, and lidocaine groups respectively (P<0.01). Incidence of mild, moderate, and sever pain were significantly lower in groups K, L, and M compared to group C (P0.05). Conclusion:Intravenous pretreatment of magnesium, ketamine, and lidocaine are same effect in attenuating propofol-induced pain.

Item Type: Article
Uncontrolled Keywords: Propofol, Magnesium, Ketamine, Lidocaine, Injection pain
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 17:50
Last Modified: 04 Jan 2018 17:50
URI: http://eprints.mazums.ac.ir/id/eprint/3216

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