Evaluation of the analgesic effect of Brassica nigra in mice

Haidari, M.R and Abbasifard, M (2002) Evaluation of the analgesic effect of Brassica nigra in mice. Journal of Mazandaran University of Medical Sciences, 12 (34). pp. 18-27.

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Official URL: http://jmums.mazums.ac.ir/article-1-69-en.html


Background and purpose: Brassica nigra is used traditionally to relieve neurotic and rheumatic pains. The aim of this study was to evaluate the analgesic effect of this plant. Materials and methods: Percolated extract of Brassica nigra with different doeses were injected intraperitonealy to mice and the analgesic effect was determined by tail flick and formalin test. Results: �n formalin test, the percolated formalin with doeses of 100, 200 and 300 mg/kg. �ould have significant analgesic property compare to control group, and 300 mg/kg of the extract had the highest analgesic property. � comparison of analgesic property of 300 mg/kg percolated extract with 2.5 mg/kg of morphine and 300 mg/kg of �S� in formalin test indicated that there was no significant difference between the analgesic property of extract, �.S.� and morphine in first phase of pain. �n chronic phase, the analgesic property of extract with significant difference (P<0.05), was better than �.S.�, but in this phase, compare to morphine, no significant difference was observed. The analgesic property of 300 mg/kg of extract did not show any significant difference with 2.5 mg/kg of morphine at 15, 30 and 90 minutes of tail-flick test. No significant difference was observed between analgesic property of extract and �.S.� at 15, 30 and 45 minutes after injection. By tail-flick method, there was significant reduction in analgesic property of extract in combination with naloxane at 15 and 30 minutes (P<0.05). �onclusion: �n this study, it was shown that the extract of Brussica nigra, has satisfactory analgesic property, hence, more investigation should be done.

Item Type: Article
Uncontrolled Keywords: Mustard, Pain Measurement (Formalin test), Rats laboratory, �nalgesics, Plants, Medicinal
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 18:09
Last Modified: 04 Jan 2018 18:09
URI: http://eprints.mazums.ac.ir/id/eprint/2766

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