The Relationship between Epstein-Barr Virus (EBV) and Virus-Encoded BARF-1 Gene in Gastric Adenocarcinoma

Ghasemi, M and AbedianKenari, S and Torabizadeh, ZH and Iri, N and Marjani, J and Mirabi, A.M (2011) The Relationship between Epstein-Barr Virus (EBV) and Virus-Encoded BARF-1 Gene in Gastric Adenocarcinoma. Journal of Mazandaran University of Medical Sciences, 21 (82). pp. 10-16.

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Official URL: http://jmums.mazums.ac.ir/article-1-818-en.html

Abstract

Background and purpose: Gastric carcinoma is the second leading cause of cancer death worldwide and its incidence varies considerably according to geographical location. There are multiple etiologic factors such as infection with �BV that play a role in carcinogenesis of gastric cancer, yet there is not enough evidence about pathogenesis of �BV and its relationship with gastric cancer. Thus, recognizing pathogenic genes can help improve the prognosis of the patients. The purpose of this study is to explore the relationship between �BV and �BV-encoded B�RF-1 oncogene in gastric adenocarcinoma pathogenesis. Materials and methods: �n this analytical case-control study, 200 paraffin-embedded blocks of biopsies of patients with gastric cancer and those of healthy people were selected. �fter DN� extraction, polymerase chain reaction (P�R) was used to determine �BV genome and B�RF-1 oncogene by specific primers of B�RF-1. Grade and stage of the gastric cancer biopsies were also examined. Results: The results of P�R indicated that �BV genome was detected in three cases in the case group, whereas all samples in the control group were negative for �BV. Thus, no significant relationship was observed between the two groups (P>0.05). The �BV positive gastric cancers were negative for B�RF-1 oncogene. �t was also found that 41 of the cancers were grade �, 52 grade ��, and 7 grade ���. �onclusion: The findings suggest that gastric cancer has a high prevalence in the geographical region under study however, �BV plays a minor role in the carcinogenesis of gastric adenocarcinoma.

Item Type: Article
Uncontrolled Keywords: �pstein Barr virus, gastric adenocarcinoma, B�RF-1
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 16:56
Last Modified: 04 Jan 2018 16:56
URI: http://eprints.mazums.ac.ir/id/eprint/2550

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