Immunological Evaluation of Recombinant HIV1 Virions with Novel Adjuvants in BALB/c Mice Model

Sadat, S.M and Zabihollahi, R and Javadi, F and Vahabpour, R and Siadat, S.D and Azadmanesh, K and Moshiri, A and Parivar, K and Aghasadeghi, M.R (2011) Immunological Evaluation of Recombinant HIV1 Virions with Novel Adjuvants in BALB/c Mice Model. Journal of Mazandaran University of Medical Sciences, 21 (84). pp. 13-21.

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Background and purpose: Finding an efficient vaccine against H�V infection is still a major concern and a great challenge. �n our previous study, H�V-1 virions with capability of a single replication were produced. �n the present study their immunological evaluation has been carried out to study their induction of cellular and humoral responses in mice model. Materials and methods: �n this study, first and second virion generations were produced in human H�K293T cells, and were injected to three different mice groups in three doses with or without adjuvants. �fter the last injection, immune responses were evaluated in serum and spleen cells of mice using �L�S�. Results: �lthough all animals vaccinated with different immunogen regimens did develop cellular responses, in the main group injected with novel adjuvants, the highest levels of specific antibody, �FN-γ, �L-4 an also most �FN-γ excreting cells were evident, which is suggestive of a strong cellular response in these cells. �onclusion: �n effective vaccine against H�V requires induction of strong humoral and cellular responses. Hence, these results demonstrate the high immune system stimulating capabilities of virion injection regime accompanied by M720 and �pG adjuvants, which provides the potential for an efficient H�V vaccine.

Item Type: Article
Uncontrolled Keywords: H�V-1 recombinant virions, immunological adjuvants, immunization
Depositing User: Unnamed user with email
Date Deposited: 04 Jan 2018 16:55
Last Modified: 04 Jan 2018 16:55

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