Movement Trend of Toxoplasma gondii in Different Tissues of Balb/c after Immunization with Excretory Secretory Antigens

Dadimoghaddam, Yousef and Daryani, Ahmad and Kalani, Hamed and Ahmadpour, Ehsan and Sharif, Mehdi and Ziaei, Hajar and Sarvi, Shahabeddi (2013) Movement Trend of Toxoplasma gondii in Different Tissues of Balb/c after Immunization with Excretory Secretory Antigens. Journal of Mazandaran University of Medical Sciences, 22 (2). pp. 22-27.

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Official URL: http://jmums.mazums.ac.ir/article-1-2021-en.html

Abstract

Background and Purpose: Toxoplasma gondii is an obligatory intracellular parasite in different cells of human beings and animals. The aim of this study was to evaluate presence and movement trend of T. gondii tachyzoites in different tissues of Balb/c, after immunization with Excretory Secretory Antigens (ESA). Materials and Methods This experimental survey has been performed on 24 Balb/c mice in case and control groups. For immunization of mice, two times, intervals two weeks, case group (n=12) received 40 µL ESA+40µL Adjuvant and control group got 40 µL PBS+40µL Adjuvant. Two weeks after the second immunization, mice were challenged with 1�104 alive and active tachyzoites of T. gondii RH strain and on 1, 2, 3 days and the last day (before death), after challenge different tissues of 3 mice from each group were prepared and stained with Giemsa stain and the slides evaluated for presence or absence of parasites and parasitic load. Results: Toxoplasma after intraperitoneal injection, in both case and control groups were able to movement to various tissues. In the case group receiving Excretory Secretory Antigens (ESA), parasitic load in spleen, liver and heart was less than control group. Conclusion: Hence, ESA reduced the parasitic load, but could not inhibit the distribution and presence of Toxoplasma in different tissues.

Item Type: Article
Uncontrolled Keywords: Movement trend, Toxoplasma gondii, tissues, Balb/c, immunization, Excretory Secretory Antigens (ESA)
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 16:49
Last Modified: 04 Jan 2018 16:49
URI: http://eprints.mazums.ac.ir/id/eprint/2406

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