Evaluation of Human Leukocyte Antigen-G and Interleukin-10 Expression in HIV Positive Patients and Healthy Subjects

Omrani-Nava, Versa and Abediankenari, Saeid and YazdaniCharati, Jamshid and Yahyapour, Yousef and Shobeiri, Saeideh Sadat and Mohammadi, Masoud and Ranjbaran, Hossein and Abedi, Siavash (2016) Evaluation of Human Leukocyte Antigen-G and Interleukin-10 Expression in HIV Positive Patients and Healthy Subjects. Journal of Mazandaran University of Medical Sciences, 26 (143). pp. 230-234.

Full text not available from this repository.
Official URL: http://jmums.mazums.ac.ir/article-1-9011-en.html

Abstract

Background and purpose: HILA-G is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. HLA-G expression in HIV-positive patients has been inconsistent between different studies and some suggest that Interleukin-10 (IL-10) influences the expression of HLA-G. The aim of this research was to investigate the expression of IL-10 in HIV-positive patients and its relation with TCD4+ lymphocytes. Materials and methods: In a case-control study, 20 HIV-positive patients, attending the Behavioral Consultation Center affiliated with Mazandaran University of Medical Sciences, were selected and 20 healthy volunteers were also enrolled. Expression of HLA-G was determined by Real-Time PCR. TCD4+ count and IL-10 concentration were evaluated by flow cytometry and ELISA, respectively. Results: HLA-G gene expression was significantly different between the two groups (P<0.05). IL-10 concentration increased in patients and a revers relation was seen between TCD4+ cell count and IL-10 (r= -0.4, P= 0.1). Conclusion: The results showed that the expression of HLA-G is deregulated during HIV infection and IL-10 could be considered as a biomarker of disease progression.

Item Type: Article
Uncontrolled Keywords: HLA-G, HIV, IL-10
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 18:47
Last Modified: 04 Jan 2018 18:47
URI: http://eprints.mazums.ac.ir/id/eprint/1995

Actions (login required)

View Item View Item