In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines

Abastabar, Mahdi and Akbari, Abolfazl and Akhtari, Javad and Hedayati, Mohammad Taghi and Shokohi, Tahereh and Mehrad-Majd, hasan and Ghalehnoei, Hosseein and Ghasemi, Sahar (2017) In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines. Current Medical Mycology, 3 (1). pp. 25-29.

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Official URL: http://cmm.mazums.ac.ir/article-1-151-en.html

Abstract

Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, we investigated its effects on HeLa,SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 µM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined. Results: The obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. Among all the cell lines, the highest growth inhibition rate was obtained at the 4 μM concentration of patulin.Conclusion: Our results suggested that patulin could significantly decrease tumor growth in human cervical and colorectal cancer models.  

Item Type: Article
Uncontrolled Keywords: Cancer, HeLa cells, Mycotoxin, Patulin
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 14:10
Last Modified: 04 Jan 2018 14:10
URI: http://eprints.mazums.ac.ir/id/eprint/1553

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