Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis?

zahedi, Nina and AbedianKenari, Saeed and Mohseni, Sahar and Aslani, Narges and Ansari, Saham and Badali, Hami (2016) Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis? Current Medical Mycology, 2 (3). pp. 15-19.

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Official URL: http://cmm.mazums.ac.ir/article-1-119-en.html

Abstract

Background and Purpose: Vulvovaginal candidiasis is a frequent disease affecting approximately more than 75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Dectin-1 (Y238X, rs16910526 ) was identified in patients with RVVC and hypothesized that genetic factors play an important role in susceptibility to RVVC. Herein, we aimed to survey the polymorphisms in the Dectin-1 gene, linked to susceptibility to RVVC. Materials and Methods: In the current study, blood samples were obtained from 25 patients who had frequent vulvovaginal candidiasis relapses and were diagnosed as RVVC. In addition, blood cultures were obtained from control group comprising of healthy individuals (n=25) with no history of RVVC, vaginal discharge, or itching on the day of examination. Dectin-1 Y238X gene polymorphism was investigated using Bi-PASA and DNA sequencing. Results: The analysis revealed that all of the patients were wild-type homozygous for Dectin-1 Y238X polymorphisms. None of the individuals showed heterozygous or mutant homozygous Dectin-1 polymorphism. Conclusion: No significant correlations were observed between the susceptibility to RVVC and Dectin-1 Y238X polymorphism in the Iranian population, which was not previously studied.

Item Type: Article
Uncontrolled Keywords: Candida species, Dectin-1 Y238X gene polymorphism, RVVC
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 14:04
Last Modified: 04 Jan 2018 14:04
URI: http://eprints.mazums.ac.ir/id/eprint/1532

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