Evaluating the Most Common Mutation in BRCAI and BRCA2 Genes in Women Who had Mothers with Brest Cancer and Controls

Sarvar, Faezeh and Nekoeian, Reza and Saeirad, Samira and Gharavi, Mohammad Javad and Tehrani, Mohsen and SarvarTaherabadi, Maryam and Sharif, Masoud and Abediankenari, Saei (2016) Evaluating the Most Common Mutation in BRCAI and BRCA2 Genes in Women Who had Mothers with Brest Cancer and Controls. Journal of Mazandaran University of Medical Sciences, 26 (141). pp. 137-142.

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Official URL: http://jmums.mazums.ac.ir/article-1-8595-en.html

Abstract

Background and purpose: Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer. Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of genomic mutations in BRCA1 and BRCA2, genes mutation analysis was done in BRCA1 (exon2, 20) and BRCA2 (exon11) using Real Time PCR test. We also studied 109 healthy controls without family history of breast cancer. Results: No any mutation was found in this population. Conclusion: This study showed no mutation in affected and control group. Therefore, other mutations and genes may have a role in breast cancer pathogenesis in our population.

Item Type: Article
Uncontrolled Keywords: breast neoplasms, BRCA1, mutation
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 12:29
Last Modified: 04 Jan 2018 12:29
URI: http://eprints.mazums.ac.ir/id/eprint/1405

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