Efficacy of a Triple-Drug Combination (Hydroquinone 5, Salicylic Acid 4 and Fluocinolone 0.1) in Treatment of Melasma

Hajheydari, Zohre and Bahari, Milad and Golpour, Masood and Yazdani, Jamshid and Baes, Mina and Mohammadpour, RezaAli (2015) Efficacy of a Triple-Drug Combination (Hydroquinone 5, Salicylic Acid 4 and Fluocinolone 0.1) in Treatment of Melasma. Journal of Mazandaran University of Medical Sciences, 24 (122). pp. 361-366.

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Official URL: http://jmums.mazums.ac.ir/article-1-5318-en.html

Abstract

Background and purpose: Melasma is a pigmentation of facial area that is seen mostly in women. Endocrine disorders are involved in development of melasma. This study was designed to evaluate the topical effect of a triple combination therapy in patients with melasma. Materials and methods: This clinical trial was conducted in 70 patients with melasma attending a Dermatology Clinic. All patients with melasma received triple combination (hydroquinone 5, salicylic acid 4, and fluocinolone 0.01) and vitamin C 2 for 6 months. The efficacy of treatment was evaluated based on Melasma Area and Severity Index (MASI) Score and patients� satisfaction was evaluated according to a questionnaire based on Satisfaction Index (SI). Data analysis was performed applying qui square test, binomial test, and repeated measures ANOVA. Results: Among the patients 93 were women and the mean age of participants was 35.21±7.5. Mean MASI Score was 27.07±10.24 at the beginning of the treatment and a significant decrease was seen at the end of first month (7.17±3.64), second (6.97±2.97), third (8.64±3.77), fourth (8.96±4.77), and sixth months (7.77±4.86). Conclusion: Triple combination therapy (hydroquinone 5, salicylic acid 4, and fluocinolone 0.01) was found effective in treatment of melasma and could be used as a new protocol.

Item Type: Article
Uncontrolled Keywords: Melasma, treatment, hydroquinone, fluocinolone, salicylic acid
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 14:53
Last Modified: 04 Jan 2018 14:53
URI: http://eprints.mazums.ac.ir/id/eprint/1117

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