Formulation and Evaluation of In situ Gels Containing Fluconazole

Enayatifard, Reza and Abrari, Jafar and Saeedi, Majid and Hashtroudi, Hamedeh and Siavoshian, Fatemeh (2015) Formulation and Evaluation of In situ Gels Containing Fluconazole. Journal of Mazandaran University of Medical Sciences, 24 (121). pp. 103-112.

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Official URL: http://jmums.mazums.ac.ir/article-1-5193-en.html

Abstract

Background and purpose: In Situ Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The aim of this study was to formulate and evaluate in situ oral topical gels of fluconazole based on concept of pH triggered system. Materials and methods: An in situ gel system consisting of carbopol 934, hydroxypropyl methylcellulose and sodium alginate was used in different concentrations to prolong the release of fluconazole. Fluconazole was added to polymer�s solution after being hydrated. Formulations were evaluated for gelling capacity, physical stability, pH, drug content, viscosity and in vitro release. Results: The use of carbopol as in situ gel forming agent was substantiated by the property to transform into stiff gels when the pH was raised. The gelling capacity, pH and drug content of formulations were found to be satisfactory. The viscosity range was from 60 to 104 centipoise in shear rate of 20 rpm. The formulations showed pseudoplastic flow and were able to release the drug slowly. The formulations showed no significant changes in different condition during the period of 90 days and were found to be stable. Conclusion: The ideal formulation can be utilized for the sustained release property.

Item Type: Article
Uncontrolled Keywords: In situ gel, prolonged release, carbopol, sodium alginate, hydroxypropyl methylcellulose, fluconazole
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 15:03
Last Modified: 04 Jan 2018 15:03
URI: http://eprints.mazums.ac.ir/id/eprint/1040

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