The Effect of Gelucire 50/13 on Release Rate of Naproxen in Solid Dispersions Prepared by PEG 4000

Abrari, Jafar and Saeedi, Majid and MortezaSemnani, Katayoun and EnayatiFard, Reza and Shakerian, Babak (2015) The Effect of Gelucire 50/13 on Release Rate of Naproxen in Solid Dispersions Prepared by PEG 4000. Journal of Mazandaran University of Medical Sciences, 24 (121). pp. 74-85.

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Official URL: http://jmums.mazums.ac.ir/article-1-5190-en.html

Abstract

Background and purpose: Solubility behavior of a drug is one of the key determinants of its oral bioavailability. The bioavailability may be enhanced by increasing the solubility and dissolution rate of drug by combining the drug with a hydrophilic carrier. Naproxen is a poor water non-soluble analgesic and anti- inflammatory drug. A possible way of overcoming the naproxen low aqueous solubility is to alter the physical properties of the drug by preparing a solid dispersion. In this study, Gelucire 50/13 and PEG 4000 were employed to produce solid dispersions with naproxen. Material and methods: Naproxen solid dispersions were prepared in various amounts of drug and polymer (PEG4000) using hot melting method. The influence of several amounts of gelucire 50/13 was also studied. Dissolution studies, Differential scanning calorimetry (DSC), Fourier�transform infrared spectroscopy (FTIR), and X-ray powder diffractometry (XRD) were used to evaluate any interaction between the drug and other components in solid dispersions. Results: According to dissolution study, drug release from solid dispersions and physical mixture were higher than that of the pure drug. Also, dissolution rate of solid dispersions and physical mixtures enhanced by increasing the concentration of polyetilen glycol. The result of DSC and FTIR showed that there was no chemical interaction between the drug and the polymer. XRD patterns showed the change of Naproxen Crystalline Material into Amorphous Materials. Conclusion: The increased dissolution rate of naproxen by solid dispersion technique could be due to increase wettability and hydrophilic nature of carrier and surfactants.

Item Type: Article
Uncontrolled Keywords: Naproxen, solid dispersion, polyethylene glycol 4000, gelucire 50/13, dissolution rate
Depositing User: Unnamed user with email eprints@mazums.ac.ir
Date Deposited: 04 Jan 2018 15:06
Last Modified: 04 Jan 2018 15:06
URI: http://eprints.mazums.ac.ir/id/eprint/1037

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